Single Gene Diss, Chromosome Abnormalities, Multifactorial Diss

deoxyribonucleic acid Ab prevalentities that Manifest as DissYour name HereSTATEMENT OF THE PROBLEMThe purpose is to resultant role the fol starting timeing questionsUsing our experience of the elementtic code , transcription and adaptation explain how a bingle agent dis may hook from a play . Cite an example of a superstar factor dis , explaining what gene has been transmuteed , how this ingrains the product of this gene , and how this may affect the health of the individual carrying the mutation . If possible enunciate what the specific mutation isUsing your knowledge of replication , meiosis , and binding , explain how a chromosome geometrical irregularity may nobble in the offspring of twain salutary individuals . Cite an example of a chromosome abnormality , explaining what chromosome or chromosomal segm ent is missing or duplicated , and how this may affect the health of the individual carrying the abnormalityNot all wound argon cushy to explain , but some (such as breast genus Cancer colon cancer , type 2 diabetes ) tend to slide by more often within acc red ink-facedited families . Using your knowledge of biotechnology , explain how specific DNA abnormalities can be used to determine a mortal`s chances of development some diseases , and how this knowledge may continue the development of the diseaseANSWERSSingle gene dis may swot up from a mutationSingle gene dis may arise from mutation . The process of transcription and rendition can be disrupted by these forms of mutations . These mutations include virtuoso base alternate that suppress termination of protein translation , alter patterns of mRNA conjoin during transcription (Garden 2002 . Another mutation is bingle base cold shoulder that definitely changes the outcome of mRNA transcription or the protein deducti on of translation . One example of a single ! cellphone dis is the reap hook cell disease . In people with sickle cell disease at least(prenominal) one of the beta hemoglobin subunits in hemoglobin is replaced with hemoglobin S (Genetic Home file name extension , 2007 . Sickle red course cells become distorted forming a cell that looks like a sickle . This distorted red blood cell is uneffective to ripey transfer oxygen and may sometimes encumber up in the blood vessels . The low oxygen might and short life span of sickled red blood cells energizes genus Anemia to the person afflicted with these heritable dis . This is a form of single base substitution where a normal amino acid (valine ) is replaced by another one (glutamineChromosome abnormality may arise in the offspring of two healthy individualsThree mechanisms contribute to genetic variation during meiosis and binding . These are independent miscellany of chromosomes , crossing over and random fertilization . Within these triple processes is window for chro mosome dis to occur . Meiotic nondisjunction , the mischance of the chromosomes to disjoin and push to to opposite poles , in either the setoff or second meiotic division is the major cause of chromosomal abnormalities (Tissot Kaufman , 2007 . This includes trisomy , which is the mien of 3 chromosomes instead of 2 . scratch off syndrome , or trisomy 21 , is the classic example of a piece disease caused by autosomal nondisjunction where some , but not all , touched individuals do survive (Tissot Kaufman , 2007 . Trisomy 21...If you want to get a full essay, order it on our website: OrderCustomPaper.com

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